IL6 and schizophrenia: However, dysregulation of the inflammatory response can trigger a cascade that affects neuronal development and subsequent downstream behavioral phenotypes. Our results are suggestive of elevation of IL-6 levels and reduction in GMV, with the largest associations within the MTG, a key area of language, semantic memory processing, and sensory integration implicated in a number of neuropsychiatric disorders. These findings extend recent evidence of association between inflammation and brain structure in schizophrenia and depression and address uncertainties of smaller samples and confounding.