Furthermore, BC patients with Cobll1+/SH3BP1+ or Cobll1+/PACSIN2+/SH3BP1+ showed a higher blast percentage than those without any expression of the three proteins, indicating that Cobll1 and SH3BP1 can aggravate disease progression in CML. Here, PACSIN2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.