While none of the three proteins were expressed at the CP, more than half of BC patients showed expression of both Cobll1 and SH3BP1 with two representative patterns (Cobll1+/SH3BP1+ and Cobll1+/PACSIN2+/SH3BP1+) These data suggest that the interactions between Cobll1, PACSIN2, and SH3BP1 are closely linked to BC transformation, TKI resistance, and sustained hematopoiesis. The gene discussed is COBLL1; the disease is breast cancer.