Furthermore, BC patients with Cobll1+/SH3BP1+ or Cobll1+/PACSIN2+/SH3BP1+ showed a higher blast percentage than those without any expression of the three proteins, indicating that Cobll1 and SH3BP1 can aggravate disease progression in CML. The gene discussed is COBLL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.