SOCS2 and ovarian cancer: Because gene expression can be regulated by methylation of the promoters or enhancer elements of the gene, and hypermethylation of SOCS2 CpG islands was detected in 14% of ovarian cancer patients (Sutherland et al., 2004), we hypothesized that N-RasG12D may suppress Socs2 expression by changing methylation of Socs2 promoter.