As shown in Fig. 4E, overexpression of SOCS2 only inhibited cell proliferation of AMLs carrying RAS mutations (OCI-AML3) but had minimal effect on FLT3-ITD mutant (MOLM13) or RAS and FLT3 wild-type (OCI-AML2) AML cells. This evidence concerns the gene SOCS2 and acute myeloid leukemia.