For all three regions of SOCS2 locus we examined, H3K27ac levels were significantly decreased in NRAS-mutant AML cell lines OCI-AML3 and HL-60, when compared with RAS wild-type AML lines OCI-AML2 and MOLM13 (Fig. 5B). The gene discussed is RUNX2; the disease is acute myeloid leukemia.