As shown in Fig. 4E, overexpression of SOCS2 only inhibited cell proliferation of AMLs carrying RAS mutations (OCI-AML3) but had minimal effect on FLT3-ITD mutant (MOLM13) or RAS and FLT3 wild-type (OCI-AML2) AML cells. Here, FLT3 is linked to acute myeloid leukemia.