HIV infection is characterized by continuous loss of CD4+ T cells leading to immunodeficiency, opportunistic infections and death.(17) A paradigm shift has changed the idea of the disease being fatal, and the results of antiretroviral therapy have led to the disease being treated as a chronic condition, with infected patients living longer and aging with a life expectancy similar tho that of the general population.(5). The gene discussed is CD4; the disease is HIV infectious disease.