Studies investigating associations between ADRB2 gene variants and response to bronchodilators or disease severity in patients suffering from asthma and chronic obstructive pulmonary disease yielded conflicting results in different populations.(7,8,22-24) In a national study conducted by de Paiva et al., in the matter of the p.Arg16Gly variant, who were homozygous for the arginine allele had a higher risk of asthma development. The gene discussed is ADRB2; the disease is chronic obstructive pulmonary disease.