In other studies, genotype AA (p.Arg16Gly) was associated with poor chronic obstructive pulmonary disease control and greater need of antimicrobial treatment due to exacerbations.(10) Genotype AA (p.Arg16Gly) may also be associated with higher risk of acute attacks, particular in regular users of long-acting bronchodilators.(27,28) Along the same lines, Turner et al. conducted a meta-analysis of data from five cross-sectional studies reporting on ADRB2 genotyping, type of treatment and exacerbations in 4,226 children. The gene discussed is ADRB2; the disease is chronic obstructive pulmonary disease.