CD3E and skin neoplasm: Chronic stress may also increase skin cancer susceptibility by shifting the balance of protective versus suppressive immune responses.(20) There is suppression of type 1 cytokines, interleukin (IL)-12p40 gene expression, CCL27/CTACK, CD3ε, and infiltration of TCD4+ and CD8+ cells at the sites of emergence, which may affect tumor progression.(20)