Previous reports have suggested that the development of MetS is associated with increased levels of inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), interleukin 1 (IL-1), etc. (Festa et al. 2000; Wisse 2004; Akbari et al. 2018; Tabrizi et al. 2018, 2019). The gene discussed is TNF; the disease is metabolic syndrome.