IL10 and coronary artery disorder: However, the infants with DS/CHD in the Huggard et al. study were >6 weeks post-operative when sampled.23 Alterations in IL-10 peri-operatively in children with DS/CHD may reflect higher local inflammation secondary to the larger defect such as cAVSD, which requires a significantly longer cardiopulmonary bypass time and cross-clamp time.