We performed MD simulations for three allosteric systems, i.e., (i) the allosteric regulation of Pin1 induced by ligand binding, (ii) the conformational transition of SOD1 by G93A amyotrophic lateral sclerosis-linked mutation, and (iii) the activation of MEK1 by oncogenic mutations. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.