IFIH1 and infection: In VACV∆C7L-infected Ifih1−/−Sting1gt/gt mice, we observed infectious virions persisted in monocytes from Ifih1−/−Sting1gt/gt mice at day 5 post-infection with VACV∆C7L but were cleared in Lyve1− IMs despite of lacking MDA5 and STING (Supplementary Fig. 6h).