In addition, we used inhibitors of caspase-1, NLRP3 and GSDMD-N, verifying that inhibition of the pyroptosis process could significantly mitigate proteinuria and kidney damage in PHN rats, indicating the potential for the treatment of MN with inhibitors of Caspase-1, NLRP3, and GSDMD-N. This evidence concerns the gene CASP1 and Nephropathy.