An in vitro study using AdipoR1 and AdipoR2 siRNAs in HCMs highlighted the same significant role-play assigned to both AdipoR1 and AdipoR2 in exerting cardioprotective effects under the presence of excess HG and PA media, which mimics the condition similar to type 2 diabetes. This evidence concerns the gene ADIPOR1 and type 2 diabetes mellitus.