APOE and hypertensive disorder: Greater WMH was related to older age in both APOE-ε4 non-carriers (standardized β value (βstd) = 0.46 [95% ci, 0.28, 0.64], p < 0.001) and APOE-ε4 carriers (βstd = 0.42 [95% ci, 0.18, 0.66], p = 0.001), and was related to HTN (βstd = 0.53 [95% ci, 0.13, 0.92], p = 0.010) in APOE-ε4 non-carriers only (Supplemental Fig. 1A, B).