APOE and Alzheimer disease: Importantly, Rab5 activation recapitulates prodromal features of AD, including endosomal enlargement and synaptic dysfunction [64], Rab7b granules are found in the EC of Lewy Body dementia patients [65], and altered Rab7 colocalizes with Aβ in apoE treated microglia [66]; that said, altered Rab GTPase levels are thus far correlative in APOE4 background, and their individual contributions to pathology or therapeutic potential remain elusive [67].