Since our findings show that PNU-282987, a selective α7nAChR agonist, can improve the lesioned skin of IMQ-stimulated mice as well as IL-6/IL-22 induced HaCaT cells, we next investigate the effect of Methyllycaconitine citrate (METH), a selective α7nAChR antagonist, on IMQ-induced psoriasis. This evidence concerns the gene CHRNA7 and psoriasis.