The IL-15 pre-conditioned cultures exhibited an apoptotic rate around 23.16 ± 4.7% in HC and 27.07 ± 4.01% in NB patients, while the cultures pre-conditioned only with IL-2 presented with a ratio of 47.46 ± 4.54% in HC and 43.66 ± 3.61% in NB patients. This evidence concerns the gene IL2 and neuroblastoma.