The controversy is reflected in the potential tumor-suppress role of MEIS1 in prostate cancer30 and clear cell renal cell carcinoma31 and that depletion of MEIS1 as well as MEIS2 enhanced tumor growth by upregulating c-MYC and CD142,7 but the oncogenic role of MEIS1 in glioma.32,33 Therefore, the functions of MEIS1 in different solid tumors need to be further elaborated. This evidence concerns the gene MYC and glioma.