PREP and cancer: Although the TALE family members are involved in biochemical functions clearly intertwining with the cancer phenotypes, they are rarely reported to be the direct inducers of cancers.11 To explore basic features of TALE family members in cancers, we used single-sample gene set enrichment analysis (ssGSEA) to score three subfamilies of TALE-like genes (e.g., PREP, PBC, and MEIS) for describing their expression landscape in a variety of cancers compared to normal samples from The Cancer Genome Atlas (TCGA) (Fig. 1a and Supplementary Fig. S1a).