Moreover, it has been shown that the BRAFV600E mutation is related to the methylation of MEIS1 in CRC.19 In this study, almost all CRC samples exhibited hypermethylated promoter regions of MEIS1, regardless of BRAF was mutated or not, and the methylation level is the highest in BRAFp.V600E group in TCGA dataset and our cohort. The gene discussed is BRAF; the disease is colorectal carcinoma.