Moreover, it has been shown that the BRAFV600E mutation is related to the methylation of MEIS1 in CRC.19 We analyzed the association between BRAF mutation and MEIS1 in TCGA dataset and discovered that the promoter regions of MEIS1 were all hypermethylated compared to normal, regardless of the presence or absence of BRAF mutations, and the methylation level of MEIS1 promoter regions is the highest in BRAFp.V600E group (Supplementary Fig. S5e). This evidence concerns the gene MEIS1 and colorectal carcinoma.