With the aim of investigating tumor-suppress roles of MEIS members, we focused on MEIS1 with significantly diminished expression in TCGA Colon Adenocarcinoma (TCGA-COAD) dataset, which was further validated with external Gene Expression Omnibus (GEO) datasets including GSE21510,12 GSE32323,13 GSE9346,14 and GSE6965715,16 (a gene expression profiles of CRC patients treated with oxaliplatin chemotherapy) (Fig. 1c). Here, MEIS1 is linked to colorectal carcinoma.