MEIS1 and colon adenocarcinoma: With the aim of investigating tumor-suppress roles of MEIS members, we focused on MEIS1 with significantly diminished expression in TCGA Colon Adenocarcinoma (TCGA-COAD) dataset, which was further validated with external Gene Expression Omnibus (GEO) datasets including GSE21510,12 GSE32323,13 GSE9346,14 and GSE6965715,16 (a gene expression profiles of CRC patients treated with oxaliplatin chemotherapy) (Fig. 1c).