To investigate whether MEIS1 manipulates biological behaviors of CRC cells, we utilized two independent small interfering RNAs (siRNAs) to impair MEIS1 expression in CRC cell lines (Caco2 and SW480) with higher basal expression of MEIS1 (Fig. 2a), and elevated MEIS1 expression in cell lines (HCT116 and HCT8) with lower basal expression of MEIS1 (Fig. 2b). This evidence concerns the gene MEIS1 and colorectal carcinoma.