Multiple studies have indicated that various lncRNAs can lead EZH2 to locate on target genes specifically, regulating their transcription transcription.21,22 Therefore, we took into account 78 lncRNAs binding to EZH2 predicted by catRAPID and 59 upregulated lncRNAs in CRC samples from TCGA dataset and intersected them to obtain upregulated lncRNAs binding to EZH2, including ELFN1-AS1, PVT1, and SNHG15 (Fig. 6a). Here, PVT1 is linked to colorectal carcinoma.