By contrast, expression of ISGs in patients strongly correlated with expression of PRRs but not with expression of MAVS, OTUD4, ABCE1, and RNase L. One possible explanation could be that tumor cells with high PPRs, MAVS, OTUD4, ISGs, and RNAse L are undergoing cell death and are thus counterselected. The gene discussed is ABCE1; the disease is neoplasm.