These results also align with the AD pathophysiology, with Aβ proteins starting to change and plateauing earlier in the AD continuum making them less informative for predicting much later cognitive decline, while p-tau continues to increase through the prodromal stage of the disease to the dementia stage, shown both in studies using CSF [24–26] and plasma [27, 28] biomarkers. This evidence concerns the gene MAPT and Alzheimer disease.