Vitamin D (1,25(OH)2D3) was injected intraperitoneally at a dose of 7 μg/kg per day for two weeks to examine its effect on diabetic mice exposed to PM. Then, blood glucose, serum creatinine, and alanine aminotransferase (ALT) levels were measured at the end of the experiment. Compared with the STZ + PM group, 1,25(OH)2D3 significantly reduced the blood glucose levels in STZ-induced diabetic mice with PM exposure (STZ + PM + 1,25(OH)2D3), indicating that vitamin D mitigated hyperglycemia in diabetic mice. Here, GPT is linked to Hyperglycemia.