Our data indicated that SETD8 overexpression decreased hyperglycaemia-induced ELK1 and bach1 expression, as well as EndMT in the kidneys (Fig. 7a, c–k; Additional file 7: Fig. S6b–e), and improved renal dysfunction in rats (Additional file 8: Fig. S7a–f). Here, KMT5A is linked to Hyperglycemia.