Our previous studies indicated that SETD8 participates in hyperglycaemia-mediated increases in endothelial adhesion molecule expression [40], proinflammatory enzymes, proinflammatory cytokine production [29], and antioxidant imbalance [30], thus mediating vascular endothelial injury [29–31, 40]. Here, KMT5A is linked to Hyperglycemia.