For example, USP10 interacts with and stabilizes YAP/TAZ and SMAD4 to promote the proliferation of hepatocellular carcinoma [36, 37], while another study indicated that USP10 inhibited the poly-ubiquitylation of AMPKα and PTEN to suppress hepatocellular carcinoma progression [38]. Here, SMAD4 is linked to hepatocellular carcinoma.