Taken together, we firstly discover that circWSB1 is dramatically induced by HIF1α under hypoxic conditions and could bind with USP10 to disrupt the interaction between USP10 and p53, which leads to the poly-ubiquitination and subsequent degradation of p53, thus assisting tumor cells to survive under hypoxia and promoting the progression of BC. This evidence concerns the gene USP10 and neoplasm.