As the main cellular receptor for SARS-CoV-2, ACE2, and the major viral fusogenic membrane-associated protease, TMPRSS2, are under transcriptional regulation by androgens [7], it had been predicted that men would present a higher propensity of infection by SARS-CoV-2 and to develop more severe disease than women [7, 8]. The gene discussed is ACE2; the disease is infection.