It has potential application value to interfere PD-L1 protein synthesis in drug-resistant GBM cells by using siPD-L1. However, lack of suitable siPD-L1 delivery vector and easy degradation of siPD-L1 in blood circulation are the main obstacles that limit the application of siPD-L1 in the treatment of GBM [28, 29]. Here, CD274 is linked to glioblastoma.