EGFR and non-small cell lung carcinoma: Non-platinum cytotoxic single-agent chemotherapy (e.g., docetaxel or pemetrexed) is currently one of the standard treatments in the second-line setting after first-line platinum-based chemotherapy for advanced NSCLC patients not harboring oncogenic drivers, such as mutations in the epidermal growth factor receptor (EGFR) gene or translocations of the anaplastic lymphoma kinase gene.