Therefore, in order to improve the validity of our conclusion that metabolism disorders, especially lipid metabolism disorder, contribute to the mechanisms underlying phlegm-damp syndrome, the differences between ApoE−/− mice and ApoE+/+ mice under specific environmental conditions (high temperature/high humidity/high-fat diet) as well as the differences between ApoE−/− mice with and without environmental challenges are needed to be further studied. This evidence concerns the gene APOE and metabolic disease.