Previous GWASs have identified six RLS risk loci (MEIS1, BTBD9, MAP2K5, PTPRD, TOX3, and an intergenic region on chromosome 2p14) [14–17]; however, only MEIS1 has been found to be associated with RLS in patients with migraine via candidate gene approach [24]. The gene discussed is PTPRD; the disease is migraine disorder.