Furthermore, multiple logistic regression analysis of age, diabetes mellitus and hypertension, copeptin, CRP, ferritin and D-dimer with COVID-19 severity found that copeptin was an independent predictor for COVID-19 severity (OR = 2.001, 95% CI: 1.388–3.596, p = 0.003) as shown in Table 4. This evidence concerns the gene AVP and hypertensive disorder.