Since the above analysis implied that CD101 expression was associated with immune response and ECM in glioma, it inferred that CD101 is involved in mediating ECM formation and lymphoid-tumor-infiltered myeloid cell interactions, thereby playing a key role in the regulation of immune cell infiltration as well as remodeling of the tumor immune microenvironment of glioma. The gene discussed is CD101; the disease is central nervous system cancer.