C3a and C5a bind to the anaphylatoxin receptors: C3aR, C5aR1, and C5aR2 and C5a is also able to activate endothelial cells in COVID-19 patients leading to von Willebrand Factor (vWF) and p-selectin exposure on the endothelial lining thereby contributing to the thrombotic phenotype (76). The gene discussed is C5AR1; the disease is COVID-19.