Together with the GSVA results that multiple stroma-regulatory pathways (e.g. TGFβ, myogenesis, IL-6 and IL-2) were upregulated in WT tumors (Figure 1C), our data implied that m6A signaling disturbance caused by genomic alterations may impact PCa progression via, at least partially, reshaping the TME. The gene discussed is TGFB1; the disease is posterior cortical atrophy.