Specifically, the IC50 values of six drugs targeting EGFR, ABL, RAF and MEK were positively correlated with m6Avalue (indicating drug resistance), whereas the IC50 values of another six drugs targeting TOP1, HDAC, GS, ALK and CDK4 were negatively correlated with m6Avalue (indicating drug sensitivity) (Figure 7A), pointing potential therapeutic strategies that aggressive PCa might be more sensitive to these drugs. Here, CDK4 is linked to posterior cortical atrophy.