EGFR and cancer: Although the upregulation of EGFR has been observed in, and causally associated with, many cancers (74,75), our data showed that m6Avalue negatively correlated with EGFR expression in pri-PCa (Figure 7B) and, consistently, patient’s tumor with higher expression of EGFR had lower GS and tumor stage (Supplementary Figure S7A) and ultimately a better prognosis (Figure 7C).