Moreover, pairwise correlation analysis highlighted a significant, but non-category-specific (i.e. writer, eraser or reader) co-expression pattern among the majority of m6A regulators (Supplementary Figure S2A), except that METTL3 negatively correlated with ZC3H13 and erasers (FTO and ALKBH5) due to their downregulation in PCa (Figure 2A). The gene discussed is ALKBH5; the disease is posterior cortical atrophy.