The above arguments explain why IgE, IL-4/IL-13 receptors, IL-5 and its receptor, as well as alarmins and their receptors represent suitable molecular targets for current and prospective biological therapies of severe asthma (Pelaia et al., 2020; Pelaia et al., 2022; Busse et al., 2021; Porsbjerg et al., 2020; Albrecht, 2021). Here, IL4 is linked to asthma.