Eosinophilic airway infiltration is the dominant effector inflammatory trait of type-2 (T2) allergic or non-allergic asthma, driven by interacting innate and adaptive immune responses orchestrated by group 2 innate lymphoid cells (ILC2) and T helper 2 (Th2) lymphocytes, producing the interleukins 4 (IL-4), 13 (IL-13), and 5 (IL-5) (Nelson et al., 2020; Rodriguez-Rodriguez et al., 2021; Hammad and Lambrecht, 2021). This evidence concerns the gene IL4 and allergic asthma.