In a basic study, using a pressure overload mouse model induced by Ang II-infusion, the researchers found that administration of monoclonal antibodies targeting CD22, another important molecule present on the surface of B cells, led to decreased myocyte hypertrophy and myocardial fibrosis, as well as reduced concentrations of inflammatory cytokines, such as IL-1β and TNF-α(Cordero-Reyes et al., 2016). This evidence concerns the gene TNF and Myocardial fibrosis.