By regulating NF-κB, STAT3, EGFR, mTOR, VEGF and other signaling pathways, it exerts a wide range of anti-cancer effects, including cancer cell cycle arrest, retardation and apoptosis, migration, epithelial-mesenchymal transition, inhibiting cancer cells proliferation, invasion and tumor angiogenesis (Samarajeewa et al., 2013; Rauf et al., 2018). The gene discussed is VEGFA; the disease is cancer.