However, this study found that HNK has a definite relationship with UFL1 and BRE1B and can promote the combination of UFL1 and BRE1B with HIF-1α, which improves the ubiquitination degradation level of HIF-1α to a certain extent, and then reverses tumor growth via the glycolytic pathway (Figure 6). This evidence concerns the gene RNF40 and neoplasm.