Specifically, HIF-1α accumulated in tumor cells is dimerized with HIF-1β, which binds to the hypoxia response element (HRE) in the transcription regulation region of the glucose transporter or other metabolic rate-limiting enzyme genes to promote their expression, resulting in reprogramming of cancer cell metabolism (Semenza, 2011a; Semenza, 2011b). Here, HIF1A is linked to cancer.