Recent research found, in the trigeminal ganglion, TRP channels co-localize with CGRP (Shibata and Tang, 2021), and the number of CGRP and TRPV1 immune reaction cells increase in the trigeminal ganglion of migraine rats (Chung-Chih et al., 2019). This evidence concerns the gene TRPV1 and migraine disorder.