GSDMD is the executive molecule in pyroptosis, and N-terminal fragments of GSDMD (GSDMD-N), which induce pyroptosis, are markedly upregulated in the livers of patients with NAFLD/NASH (Xu et al., 2018), and are essential in the pathogenesis of steatohepatitis, through regulation of cytokine secretion, control of nuclear factor-κB (NF-κB) activation, and inhibition of lipogenesis. Here, GSDMD is linked to metabolic dysfunction-associated steatohepatitis.