Mirea et al. (2020) showed that caspase-1 deficiency ameliorated diet-induced weight gain, adipose tissue inflammation, and liver steatosis. Another group also demonstrated that mice deficient of caspase-1 were protected from HFD or MCD diet-mediated early fibrogenesis, hepatic steatosis, and inflammation (Dixon et al., 2012; Dixon et al., 2013). Furthermore, other studies have indicated that caspases-1/11 have active roles in NAFLD by modulating the composition and diversity of the gut microbial community and regulating liver lipid composition and metabolism (de Sant'Ana et al., 2019). Here, CASP1 is linked to fatty liver disease.