NLRP3 and metabolic dysfunction-associated steatohepatitis: In mouse models of NASH induced by a high-fat, high-cholesterol diet, exposure of Kupffer cells, hepatocytes, and bone marrow macrophages to cholesterol crystals stimulates NLRP3 inflammasome activation and mediates NASH development (Ioannou et al., 2015; Mridha et al., 2017).