Although other types of inflammasome are also related to liver diseases, NLRP3-containing inflammasome has been widely studied in this context, and multiple studies have demonstrated that NLRP3 inflammasome is a key contributor to amplification of hepatic inflammation, immune cell activation, and hepatocyte damage (Szabo and Petrasek, 2015; Swanson et al., 2019). The gene discussed is NLRP3; the disease is liver disorder.