CASP1 and metabolic dysfunction-associated steatotic liver disease: Mirea et al. (2020) showed that caspase-1 deficiency ameliorated diet-induced weight gain, adipose tissue inflammation, and liver steatosis. Another group also demonstrated that mice deficient of caspase-1 were protected from HFD or MCD diet-mediated early fibrogenesis, hepatic steatosis, and inflammation (Dixon et al., 2012; Dixon et al., 2013). Furthermore, other studies have indicated that caspases-1/11 have active roles in NAFLD by modulating the composition and diversity of the gut microbial community and regulating liver lipid composition and metabolism (de Sant'Ana et al., 2019).