Levels of inflammasome components, including NLRP3, caspase-1, pro-IL-1β, and pro-IL-18, are significantly higher in liver samples from patients with NASH than in those without the disease, and their expression is associated with the development/degree of fibrosis (Csak et al., 2011; Wree et al., 2014). This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.