TARDBP and proteostasis deficiencies: This includes disease due to a wide range of genetic mutations [TARDBP (encodes TDP-43 protein), PGRN, UBQLN2, SQSTM1, PFN1, ANG, VCP, MATR3, TUB4A and C9ORF72], which implicates shared disease mechanisms and a causative role for TDP-43 proteinopathy.1