The lncRNA DLX6 antisense RNA1 (DLX6-AS1) and the function of lncRNA maternally expressed gene 3 (MEG3) could function as the enablers of cell pyroptosis in LPS-induced AKI by decreasing miR-223-3p and targeting MEG3/miR-21/PDCD4 axis and miR-18a-3p/GSDMD, respectively (Yang et al., 2018; Tan et al., 2020; Deng et al., 2021a). The gene discussed is PDCD4; the disease is acute kidney injury.