ACE2 and infection: It is now established that infection with the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) virus typically initiates in the upper respiratory tract (e.g., nasal-oral cavities), highlighting the nasal susceptibility to SARS-CoV-2 due to higher presence of angiotensin-converting enzyme 2 (ACE2) expression in the nasal epithelium with decreasing expression throughout the lower respiratory tract (Hou et al., 2020).