Evidence suggests that the elevations in pro-inflammatory cytokines observed in obesity, including interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and serum amyloid, can be reduced via weight loss [85–88]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.