Compared with the control, overexpression was observed of JCPyV T antigen, Akt, survivin, retinoblastoma protein (Rb), β-catenin, β-transducin repeat-containing protein (TRCP), and inhibitor of growth (ING) 1 in T-antigen-overexpressing hepatocellular and pancreatic cancer cells and spontaneous hepatocellular carcinoma or pancreatic adenocarcinoma tissues, while the underexpression of mammalian target of rapamycin (mTOR), p-mTOR, p-p38, Cyclin D1, p21, VEGF, ING2, and ING4 was noted (Figure 5). Here, RB1 is linked to familial pancreatic carcinoma.