At the time hypophysitis developed, patients were receiving ipilimumab plus nivolumab (77%; 53/69), anti-PD-(L)1 monotherapy (12%; 8/69), anti-PD-(L)1 with the addition of an investigational agent (6%; 4/69), or ipilimumab monotherapy (6%; 4/69) (Table 1). Here, CD274 is linked to hypophysitis.