Past researches revealed that the expression level of PUDP may be a prognostic biomarker for colorectal cancer and demonstrated that the overexpression of PUDP conferred 2-deoxyglucose(2DG) resistance in HeLa cells, suggesting that it may be a conserved regulator of 2DG resistance and could interfere 2DG-based chemotherapies (13, 14). The gene discussed is PUDP; the disease is colorectal cancer.