TARDBP and Brain atrophy: Many previous studies have noted that hippocampal sclerosis is associated with hippocampal atrophy,32–34 and one study has even noted associations outside the medial temporal lobe.35 In addition, other studies have found TDP-43, the proteinopathy signature of hippocampal sclerosis, to be associated with hippocampal25 and additional brain atrophy.36 However, it is unclear how the relationship between hippocampal sclerosis pathology and atrophy may change when accounting for cognitive status.