Bjorklund et al. developed a nongenetic mouse model of atherosclerosis induced by a single injection of recombinant adeno-associated virus (rAAV) encoding a hyperactive proprotein convertase subtilisin/kexin type 9 (PCSK9)D377Y mutant followed by high-fat diet (HFD) feeding that has been used in nondiabetic settings (7, 8) as well as in mature diabetic Akita mice, where they showed diabetic-associated accelerated atherosclerosis (7). Here, PCSK9 is linked to atherosclerosis.