CD274 and neoplasm: These immunotherapy agents block the interaction between the PD-1 ligand (PDL-1) and PD-1 receptor by inhibiting either PD-1 (nivolumab and pembrolizumab) or PDL-1 (atezolizumab and durvalumab), and this inhibition, in turn, promotes the ability of T-cells to recognize and destroy tumor cells [1].