MAN2A2 and Alzheimer disease: Simultaneously, we also detected many candidate genes related to superior breed characteristics in two population-specific ROH hotspots, such as sperm development (PSMA8, ADAD1, CSTF2T, and SGMS1 in AD pigs and TSGA10, MAN2A2, and ICA1L in CD pigs) and growth (FGF2 and MYOZ1 in AD pigs and RECK, XPA, TRAF6, FHL2, REV1, RANBP2, IL1R1, and SATB2 in CD pigs) traits.