Casazza et al. (2011) found that Sema3A reduces the number of pericyte-coated vessels in tumor blood vessels, which correlated with endothelial cell survival. In ischemic stroke, pericytes respond to ischemia promptly and are involved in various pathological and repair processes. We conjectured that a connection between Sema3A and pericyte dysfunction which leads to the progression of vascular diseases such as stroke (Figure 1). This evidence concerns the gene SEMA3A and neoplasm.