The present study evaluated DLPFC postmortem tissues from controls, schizophrenia Type 1 and Type 2, demonstrated S1PR1 protein is highly expressed in gray matter region, and most importantly showed that only Type 2 schizophrenia has upregulated S1PR1 protein expression in line with previous S1PR1 mRNA results. The gene discussed is S1PR1; the disease is schizophrenia.