In patients with glaucoma, the loss of retinal ganglion cells is accompanied by the accumulation of IgG autoantibodies on ganglion cell layer cells (53), and the deposition of IgG autoantibodies is accompanied by CD27 +/IgG + plasma cells, which occurs under pro-inflammatory conditions, the level of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-8 were also increased (53). The gene discussed is TNF; the disease is glaucoma.